Oral antiviral drugs in experimental herpes simplex keratitis
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چکیده
منابع مشابه
Gamma Globulin in Experimental Herpes Simplex Keratitis.
The chronic keratitis resulting from the steroid treatment of acute herpes simplex infection of the rabbit cornea was significantly improved by the subconfunctival administration of either human or rabbit gamma globulin, the latter possessing no neutralizing antibody to herpes simplex virus. Virus titrations of this late lesion were consistently negative. The etiological and therapeutic implica...
متن کاملTherapy of experimental herpes simplex keratitis.
Topical therapy with trypsin, chymotrypsin, and monoxychloroserene, and corneal scrub with iodine, ether, and silver nitrate did not demonstrably reduce the incidence of a positive virus culture from rabbit corneas infected with herpes simplex. It is suggested that the virucidal properties of such substances as measured by their effect on cell-free virus suspensions is not pertinent to the abol...
متن کاملHerpes simplex keratitis. An experimental study.
The incidence of complicated herpes simplex keratitis appears to have increased and the important factor seems to be associated with the use of topical corticosteroid hormone. A good experimental model exists for the study of herpetic keratitis. The disease corresponds to the primary infection in man. The unfavorable effects of corticosteroid hormone on experimental herpetic keratitis is reported.
متن کاملHerpes simplex keratitis in children.
Ophthalmic findings are reported in 31 eyes of 28 children with herpes simplex keratitis. Twenty two had dendritic ulcers, and nine had geographic ulcers or disciform stromal keratitis. After resolution of keratitis, 80% (19/22) of children with dendritic ulcers achieved corrected visual acuity of 6/9 or better, 50% (11/22) had induced astigmatism, 45% (9/22) had one to five recurrences. In the...
متن کاملPhosphonoacetic acid in the treatment of experimental herpes simplex keratitis.
In a rabbit model of herpes simplex corneal ulceration, 5% phosphonoacetic acid solution or ophthalmic ointment suppressed clinical disease and virus replication. The effect of 5% phosphonoacetic acid ointment was equivalent to that of 0.5% idoxuridine ointment in the treatment of this established herpetic eye infection.
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1983
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.24.6.888